Cannabis is the most widely used illicit drug in Canada. In 2015, the new Liberal government of Canada announced their plan to legalize cannabis and in June of 2016 a federal task force on cannabis was announced. Guided by this task force, cannabis legislation is expected to be introduced in 2017. To inform Alberta’s response to the federal decision to legalize cannabis, the University of Calgary Health Technology Assessment Unit developed a series of evidence syntheses to support policy development by the Government of Alberta. This resource consists of five reports that address: the Canadian Context for cannabis use and legalization; the health effects and harms of cannabis; medical cannabis; advertisement and communication regulations; and experience with legalization among jurisdictions who have legalized cannabis use.